On the other hand, grapefruit can interact with some other medicines and have the opposite effect. In addition, people have variable amounts of this enzyme CYP3A4 in their intestines and liver therefore, grapefruit juice can have a different effect on people taking the same drug. This can increase the risk of side effects like muscle damage, liver injury, and kidney failure. Grapefruit juice can block this enzyme, allowing more of the statin drug to stay in the bloodstream longer. Possible food-drug interactions can occur because grapefruit can interfere with these enzymes and transporters cells, causing blood levels of the medicine to fluctuate.įor example, statins that are used to treat high cholesterol are broken down by an enzyme called CYP3A4 in the liver and small intestine. From there, they enter the bloodstream and travel to the liver where they are metabolized (broken down) or activated by the enzymes in the liver.
When you take the drugs by mouth, they are absorbed through the transporter cells in the gut. Here’s how the potential drug interactions happen. Now you may be wondering why only certain drugs interact with grapefruit. In most cases, the drug interaction leads to increased blood levels of the medicine, causing an increased risk of side effects. Yes, there can be some food-drug interactions between grapefruit products and certain medications. Does eating grapefruit or drinking grapefruit juice affect medications? Please continue reading to learn more about some common medications with which grapefruit juice and grapefruit interact.
Do not stop taking the medication without medical advice. If your diet usually includes grapefruit and you’ve been prescribed a medicine that grapefruit juice affects, you should speak to your doctor or pharmacist. However, drinking grapefruit juice and eating grapefruit, unfortunately, can affect how some medicines work. Therefore, grapefruit juice and grapefruit can be good additions to a healthy diet.
This citrus fruit is also low in saturated fat, cholesterol, and sodium. It is a good source of nutrients like vitamin C and potassium. Grapefruit is high in nutrition and low in calories.
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